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Nav1.1 haploinsufficiency in excitatory neurons ameliorates seizure-associated sudden death in a mouse model of Dravet syndrome
Dravet syndrome is a severe epileptic encephalopathy mainly caused by heterozygous mutations in the SCN1A gene encoding a voltage-gated sodium channel Nav1.1. We previously reported dense localization of Nav1.1 in parvalbumin (PV)-positive inhibitory interneurons in mice and abnormal firing of those...
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| 主要な著者: | , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2013
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| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3820136/ https://ncbi.nlm.nih.gov/pubmed/23922229 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt331 |
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