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Up-Regulation of P2X(4) Receptors in Spinal Microglia after Peripheral Nerve Injury Mediates BDNF Release and Neuropathic Pain

ATP is a known mediator of inflammatory and neuropathic pain. However, the mechanisms by which specific purinergic receptors contribute to chronic pain states are still poorly characterized. Here, we demonstrate that in response to peripheral nerve injury, P2X(4) receptors (P2X(4)R) are expressed de...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Ulmann, Lauriane, Hatcher, Jon P., Hughes, Jane P., Chaumont, Séverine, Green, Paula J., Conquet, François, Buell, Gary N., Reeve, Alison J., Chessell, Iain P., Rassendren, Francois
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6671487/
https://ncbi.nlm.nih.gov/pubmed/18971468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2308-08.2008
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