Up-Regulation of P2X(4) Receptors in Spinal Microglia after Peripheral Nerve Injury Mediates BDNF Release and Neuropathic Pain

ATP is a known mediator of inflammatory and neuropathic pain. However, the mechanisms by which specific purinergic receptors contribute to chronic pain states are still poorly characterized. Here, we demonstrate that in response to peripheral nerve injury, P2X(4) receptors (P2X(4)R) are expressed de...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Ulmann, Lauriane, Hatcher, Jon P., Hughes, Jane P., Chaumont, Séverine, Green, Paula J., Conquet, François, Buell, Gary N., Reeve, Alison J., Chessell, Iain P., Rassendren, Francois
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2008
Schlagworte:
Brief Communications
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6671487/
https://ncbi.nlm.nih.gov/pubmed/18971468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2308-08.2008
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