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P2X4 receptors mediate PGE2 release by tissue-resident macrophages and initiate inflammatory pain
Prostaglandin E2 (PGE2) is a key mediator of inflammation and contributes to pain hypersensitivity by promoting sensory neurons hyperexcitability. PGE2 synthesis results from activation of a multi-step enzymatic cascade that includes cyclooxygenases (COXs), the main targets of non-steroidal anti-inf...
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| Main Authors: | , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group
2010
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2910276/ https://ncbi.nlm.nih.gov/pubmed/20562826 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.126 |
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