Inflammatory-induced spinal dorsal horn neurons hyperexcitability is mediated by P2X4 receptors

INTRODUCTION: Purinergic ionotropic P2X receptors (P2RX) are involved in normal and pathological pain transmission. Among them, P2X4 are expressed in dorsal root ganglion and in the spinal cord. Their activation during nerve injury or chronic peripheral inflammation modifies pain sensitivity that le...

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Bibliographische Detailangaben
Veröffentlicht in:Pain Rep
Hauptverfasser: Aby, Franck, Whitestone, Sara, Landry, Marc, Ulmann, Lauriane, Fossat, Pascal
Format: Artigo
Sprache:Inglês
Veröffentlicht: Wolters Kluwer 2018
Schlagworte:
Basic Science
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5999414/
https://ncbi.nlm.nih.gov/pubmed/29922748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/PR9.0000000000000660
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