Deletion of Neuronal GLT-1 in Mice Reveals Its Role in Synaptic Glutamate Homeostasis and Mitochondrial Function

The glutamate transporter GLT-1 is highly expressed in astrocytes but also in neurons, primarily in axon terminals. We generated a conditional neuronal GLT-1 KO using synapsin 1-Cre (synGLT-1 KO) to elucidate the metabolic functions of GLT-1 expressed in neurons, here focusing on the cerebral cortex...

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Pubblicato in:J Neurosci
Autori principali: McNair, Laura F., Andersen, Jens V., Aldana, Blanca I., Hohnholt, Michaela C., Nissen, Jakob D., Sun, Yan, Fischer, Kathryn D., Sonnewald, Ursula, Nyberg, Nils, Webster, Sophie C., Kapur, Kush, Rimmele, Theresa S., Barone, Ilaria, Hawks-Mayer, Hannah, Lipton, Jonathan O., Hodgson, Nathaniel W., Hensch, Takao K., Aoki, Chiye J., Rosenberg, Paul A., Waagepetersen, Helle S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2019
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6670249/
https://ncbi.nlm.nih.gov/pubmed/30926746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0894-18.2019
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