Deletion of Neuronal GLT-1 in Mice Reveals Its Role in Synaptic Glutamate Homeostasis and Mitochondrial Function

The glutamate transporter GLT-1 is highly expressed in astrocytes but also in neurons, primarily in axon terminals. We generated a conditional neuronal GLT-1 KO using synapsin 1-Cre (synGLT-1 KO) to elucidate the metabolic functions of GLT-1 expressed in neurons, here focusing on the cerebral cortex...

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Détails bibliographiques
Publié dans:J Neurosci
Auteurs principaux: McNair, Laura F., Andersen, Jens V., Aldana, Blanca I., Hohnholt, Michaela C., Nissen, Jakob D., Sun, Yan, Fischer, Kathryn D., Sonnewald, Ursula, Nyberg, Nils, Webster, Sophie C., Kapur, Kush, Rimmele, Theresa S., Barone, Ilaria, Hawks-Mayer, Hannah, Lipton, Jonathan O., Hodgson, Nathaniel W., Hensch, Takao K., Aoki, Chiye J., Rosenberg, Paul A., Waagepetersen, Helle S.
Format: Artigo
Langue:Inglês
Publié: Society for Neuroscience 2019
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6670249/
https://ncbi.nlm.nih.gov/pubmed/30926746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0894-18.2019
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