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Deletion of Neuronal GLT-1 in Mice Reveals Its Role in Synaptic Glutamate Homeostasis and Mitochondrial Function

The glutamate transporter GLT-1 is highly expressed in astrocytes but also in neurons, primarily in axon terminals. We generated a conditional neuronal GLT-1 KO using synapsin 1-Cre (synGLT-1 KO) to elucidate the metabolic functions of GLT-1 expressed in neurons, here focusing on the cerebral cortex...

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發表在:J Neurosci
Main Authors: McNair, Laura F., Andersen, Jens V., Aldana, Blanca I., Hohnholt, Michaela C., Nissen, Jakob D., Sun, Yan, Fischer, Kathryn D., Sonnewald, Ursula, Nyberg, Nils, Webster, Sophie C., Kapur, Kush, Rimmele, Theresa S., Barone, Ilaria, Hawks-Mayer, Hannah, Lipton, Jonathan O., Hodgson, Nathaniel W., Hensch, Takao K., Aoki, Chiye J., Rosenberg, Paul A., Waagepetersen, Helle S.
格式: Artigo
語言:Inglês
出版: Society for Neuroscience 2019
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6670249/
https://ncbi.nlm.nih.gov/pubmed/30926746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0894-18.2019
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