Conditional Deletion of the Glutamate Transporter GLT-1 Reveals That Astrocytic GLT-1 Protects against Fatal Epilepsy While Neuronal GLT-1 Contributes Significantly to Glutamate Uptake into Synaptosomes

GLT-1 (EAAT2; slc1a2) is the major glutamate transporter in the brain, and is predominantly expressed in astrocytes, but at lower levels also in excitatory terminals. We generated a conditional GLT-1 knock-out mouse to uncover cell-type-specific functional roles of GLT-1. Inactivation of the GLT-1 g...

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Publié dans:J Neurosci
Auteurs principaux: Petr, Geraldine T., Sun, Yan, Frederick, Natalie M., Zhou, Yun, Dhamne, Sameer C., Hameed, Mustafa Q., Miranda, Clive, Bedoya, Edward A., Fischer, Kathryn D., Armsen, Wencke, Wang, Jianlin, Danbolt, Niels C., Rotenberg, Alexander, Aoki, Chiye J., Rosenberg, Paul A.
Format: Artigo
Langue:Inglês
Publié: Society for Neuroscience 2015
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4380995/
https://ncbi.nlm.nih.gov/pubmed/25834045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4255-14.2015
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