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Functional Analysis of Human BRCA2 Variants Using a Mouse Embryonic Stem Cell-Based Assay

We describe here a comprehensive and reliable assay to test the functional significance of variants of unknown clinical significance (VUS) identified in the human breast cancer susceptibility gene, BRCA2. The assay is based on the ability of human BRCA2 to complement the loss of endogenous Brca2 in...

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Detaylı Bibliyografya
Yayımlandı:Methods Mol Biol
Asıl Yazarlar: Kuznetsov, Sergey G., Chang, Suhwan, Sharan, Shyam K.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2010
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6669890/
https://ncbi.nlm.nih.gov/pubmed/20721749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-60761-759-4_16
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