Functional evaluation of five BRCA2 unclassified variants identified in a Sri Lankan cohort with inherited cancer syndromes using a mouse embryonic stem cell-based assay

Next-generation sequencing of Sri Lankan families with inherited cancer syndromes resulted in the identification of five BRCA2 variants of unknown clinical significance. Interpreting such variants poses significant challenges for both clinicians and patients. Using a mouse embryonic stem cell-based...

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Bibliographic Details
Published in:Breast Cancer Res
Main Authors: Sirisena, Nirmala, Biswas, Kajal, Sullivan, Teresa, Stauffer, Stacey, Cleveland, Linda, Southon, Eileen, Dissanayake, Vajira H. W., Sharan, Shyam K.
Format: Artigo
Language:Inglês
Published: BioMed Central 2020
Subjects:
Short Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7216543/
https://ncbi.nlm.nih.gov/pubmed/32393398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-020-01272-z
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