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Mouse ES-cell-based functional assay to evaluate mutations in BRCA2

Individuals with mutations in breast cancer susceptibility genes, BRCA1 and BRCA2 have up to 80% risk of developing breast cancer by the age of 70. Sequencing based genetic tests are now available to identify mutation carriers in effort to reduce mortality through prevention and early diagnosis. How...

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Hlavní autoři: Kuznetsov, Sergey G., Liu, Pentao, Sharan, Shyam K.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2640324/
https://ncbi.nlm.nih.gov/pubmed/18607349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.1719
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