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A comprehensive functional characterization of BRCA2 variants associated with Fanconi anemia using mouse ES cell–based assay
Biallelic mutations in the human breast cancer susceptibility gene, BRCA2, are associated with Fanconi anemia, implying that some persons who inherit 2 deleterious variants of BRCA2 are able to survive even though it is well established that BRCA2 is indispensable for viability in mice. One such var...
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| Main Authors: | , , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society of Hematology
2011
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3167357/ https://ncbi.nlm.nih.gov/pubmed/21719596 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-12-324541 |
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