A comprehensive functional characterization of BRCA2 variants associated with Fanconi anemia using mouse ES cell–based assay

Biallelic mutations in the human breast cancer susceptibility gene, BRCA2, are associated with Fanconi anemia, implying that some persons who inherit 2 deleterious variants of BRCA2 are able to survive even though it is well established that BRCA2 is indispensable for viability in mice. One such var...

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Библиографические подробности
Главные авторы: Biswas, Kajal, Das, Ranabir, Alter, Blanche P., Kuznetsov, Sergey G., Stauffer, Stacey, North, Susan L., Burkett, Sandra, Brody, Lawrence C., Meyer, Stefan, Byrd, R. Andrew, Sharan, Shyam K.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society of Hematology 2011
Предметы:
Hematopoiesis and Stem Cells
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3167357/
https://ncbi.nlm.nih.gov/pubmed/21719596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-12-324541
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