A comprehensive functional characterization of BRCA2 variants associated with Fanconi anemia using mouse ES cell–based assay

Biallelic mutations in the human breast cancer susceptibility gene, BRCA2, are associated with Fanconi anemia, implying that some persons who inherit 2 deleterious variants of BRCA2 are able to survive even though it is well established that BRCA2 is indispensable for viability in mice. One such var...

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Detalhes bibliográficos
Main Authors: Biswas, Kajal, Das, Ranabir, Alter, Blanche P., Kuznetsov, Sergey G., Stauffer, Stacey, North, Susan L., Burkett, Sandra, Brody, Lawrence C., Meyer, Stefan, Byrd, R. Andrew, Sharan, Shyam K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Hematopoiesis and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3167357/
https://ncbi.nlm.nih.gov/pubmed/21719596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-12-324541
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