A comprehensive functional characterization of BRCA2 variants associated with Fanconi anemia using mouse ES cell–based assay

Biallelic mutations in the human breast cancer susceptibility gene, BRCA2, are associated with Fanconi anemia, implying that some persons who inherit 2 deleterious variants of BRCA2 are able to survive even though it is well established that BRCA2 is indispensable for viability in mice. One such var...

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Bibliografiset tiedot
Päätekijät: Biswas, Kajal, Das, Ranabir, Alter, Blanche P., Kuznetsov, Sergey G., Stauffer, Stacey, North, Susan L., Burkett, Sandra, Brody, Lawrence C., Meyer, Stefan, Byrd, R. Andrew, Sharan, Shyam K.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society of Hematology 2011
Aiheet:
Hematopoiesis and Stem Cells
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3167357/
https://ncbi.nlm.nih.gov/pubmed/21719596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-12-324541
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