A comprehensive functional characterization of BRCA2 variants associated with Fanconi anemia using mouse ES cell–based assay

Biallelic mutations in the human breast cancer susceptibility gene, BRCA2, are associated with Fanconi anemia, implying that some persons who inherit 2 deleterious variants of BRCA2 are able to survive even though it is well established that BRCA2 is indispensable for viability in mice. One such var...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Biswas, Kajal, Das, Ranabir, Alter, Blanche P., Kuznetsov, Sergey G., Stauffer, Stacey, North, Susan L., Burkett, Sandra, Brody, Lawrence C., Meyer, Stefan, Byrd, R. Andrew, Sharan, Shyam K.
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2011
Sujets:
Hematopoiesis and Stem Cells
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3167357/
https://ncbi.nlm.nih.gov/pubmed/21719596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-12-324541
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires