The flavonoid, 2′-methoxy-6-methylflavone, affords neuroprotection following focal cerebral ischaemia

Tonic inhibitory currents, mediated by extrasynaptic GABA(A) receptors, are elevated at a delay following stroke. Flavonoids minimise the extent of cellular damage following stroke, but little is known about their mode of action. We demonstrate that the flavonoid, 2′-methoxy-6-methylflavone (0.1–10 ...

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Detalhes bibliográficos
Publicado no:J Cereb Blood Flow Metab
Main Authors: Clarkson, Andrew N, Boothman-Burrell, Lily, Dósa, Zita, Nagaraja, Raghavendra Y, Jin, Liang, Parker, Kim, van Nieuwenhuijzen, Petra S, Neumann, Silke, Gowing, Emma K, Gavande, Navnath, Ahring, Philip K, Holm, Mai M, Hanrahan, Jane R, Nicolazzo, Joseph A, Jensen, Kimmo, Chebib, Mary
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2018
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6668512/
https://ncbi.nlm.nih.gov/pubmed/29376464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X18755628
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