2′-Methoxy-6-methylflavone: a novel anxiolytic and sedative with subtype selective activating and modulating actions at GABA(A) receptors

BACKGROUND AND PURPOSE: Flavonoids are known to have anxiolytic and sedative effects mediated via actions on ionotropic GABA receptors. We sought to investigate this further. EXPERIMENTAL APPROACH: We evaluated the effects of 2′-methoxy-6-methylflavone (2′MeO6MF) on native GABA(A) receptors in new-b...

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Detalhes bibliográficos
Main Authors: Karim, Nasiara, Curmi, John, Gavande, Navnath, Johnston, Graham AR, Hanrahan, Jane R, Tierney, M Louise, Chebib, Mary
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2012
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3312486/
https://ncbi.nlm.nih.gov/pubmed/21797842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01604.x
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