A Ca(v)3.2 T-Type Calcium Channel Point Mutation Has Splice-Variant-Specific Effects on Function and Segregates with Seizure Expression in a Polygenic Rat Model of Absence Epilepsy

Low-voltage-activated, or T-type, calcium (Ca(2+)) channels are believed to play an essential role in the generation of absence seizures in the idiopathic generalized epilepsies (IGEs). We describe a homozygous, missense, single nucleotide (G to C) mutation in the Ca(v)3.2 T-type Ca(2+) channel gene...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Powell, Kim L., Cain, Stuart M., Ng, Caroline, Sirdesai, Shreerang, David, Laurence S., Kyi, Mervyn, Garcia, Esperanza, Tyson, John R., Reid, Christopher A., Bahlo, Melanie, Foote, Simon J., Snutch, Terrance P., O'Brien, Terence J.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6664949/
https://ncbi.nlm.nih.gov/pubmed/19144837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5295-08.2009
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