Z944, a Novel Selective T-Type Calcium Channel Antagonist Delays the Progression of Seizures in the Amygdala Kindling Model

Temporal lobe epilepsy (TLE) is the most common form of drug resistant epilepsy. Current treatment is symptomatic, suppressing seizures, but has no disease modifying effect on epileptogenesis. We examined the effects of Z944, a potent T-type calcium channel antagonist, as an anti-seizure agent and a...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Casillas-Espinosa, Pablo Miguel, Hicks, Ashleigh, Jeffreys, Amy, Snutch, Terrance P., O’Brien, Terence J., Powell, Kim L.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2015
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4537250/
https://ncbi.nlm.nih.gov/pubmed/26274319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0130012
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