Z944, a Novel Selective T-Type Calcium Channel Antagonist Delays the Progression of Seizures in the Amygdala Kindling Model

Temporal lobe epilepsy (TLE) is the most common form of drug resistant epilepsy. Current treatment is symptomatic, suppressing seizures, but has no disease modifying effect on epileptogenesis. We examined the effects of Z944, a potent T-type calcium channel antagonist, as an anti-seizure agent and a...

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Pubblicato in:PLoS One
Autori principali: Casillas-Espinosa, Pablo Miguel, Hicks, Ashleigh, Jeffreys, Amy, Snutch, Terrance P., O’Brien, Terence J., Powell, Kim L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4537250/
https://ncbi.nlm.nih.gov/pubmed/26274319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0130012
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