Ca(V)3.2 drives sustained burst‐firing, which is critical for absence seizure propagation in reticular thalamic neurons

OBJECTIVE: Genetic alterations have been identified in the CACNA1H gene, encoding the Ca(V)3.2 T‐type calcium channel in patients with absence epilepsy, yet the precise mechanisms relating to seizure propagation and spike‐wave‐discharge (SWD) pacemaking remain unknown. Neurons of the thalamic reticu...

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Bibliographic Details
Published in:Epilepsia
Main Authors: Cain, Stuart M., Tyson, John R., Choi, Hyun‐Beom, Ko, Rebecca, Lin, Paulo J. C., LeDue, Jeffrey M., Powell, Kim L., Bernier, Louis‐Philippe, Rungta, Ravi L., Yang, Yi, Cullis, Pieter R., O'Brien, Terence J., MacVicar, Brian A., Snutch, Terrance P.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2018
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Full‐length Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5900875/
https://ncbi.nlm.nih.gov/pubmed/29468672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/epi.14018
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