Ca(V)3.2 drives sustained burst‐firing, which is critical for absence seizure propagation in reticular thalamic neurons

OBJECTIVE: Genetic alterations have been identified in the CACNA1H gene, encoding the Ca(V)3.2 T‐type calcium channel in patients with absence epilepsy, yet the precise mechanisms relating to seizure propagation and spike‐wave‐discharge (SWD) pacemaking remain unknown. Neurons of the thalamic reticu...

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Detaylı Bibliyografya
Yayımlandı:Epilepsia
Asıl Yazarlar: Cain, Stuart M., Tyson, John R., Choi, Hyun‐Beom, Ko, Rebecca, Lin, Paulo J. C., LeDue, Jeffrey M., Powell, Kim L., Bernier, Louis‐Philippe, Rungta, Ravi L., Yang, Yi, Cullis, Pieter R., O'Brien, Terence J., MacVicar, Brian A., Snutch, Terrance P.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2018
Konular:
Full‐length Original Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5900875/
https://ncbi.nlm.nih.gov/pubmed/29468672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/epi.14018
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