Matrine attenuates oxidative stress and cardiomyocyte apoptosis in doxorubicin-induced cardiotoxicity via maintaining AMPKα/UCP2 pathway

Oxidative stress and cardiomyocyte apoptosis are involved in the pathogenesis of doxorubicin (DOX)-induced cardiotoxicity. Matrine is well-known for its powerful anti-oxidant and anti-apoptotic capacities. Our present study aimed to investigate the effect of matrine on DOX-induced cardiotoxicity and...

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Detalhes bibliográficos
Publicado no:Acta Pharm Sin B
Main Authors: Hu, Can, Zhang, Xin, Wei, Wenying, Zhang, Ning, Wu, Haiming, Ma, Zhenguo, Li, Lingli, Deng, Wei, Tang, Qizhu
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
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Original article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6664099/
https://ncbi.nlm.nih.gov/pubmed/31384530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2019.03.003
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