Cytochrome c oxidase dysfunction enhances phagocytic function and osteoclast formation in macrophages

The mitochondria-to-nucleus retrograde signaling (MtRS) pathway aids in cellular adaptation to stress. We earlier reported that the Ca(2+)- and calcineurin-dependent MtRS induces macrophage differentiation to bone-resorbing osteoclasts. However, mechanisms through which macrophages sense and respond...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Angireddy, Rajesh, Kazmi, Hasan Raza, Srinivasan, Satish, Sun, Li, Iqbal, Jameel, Fuchs, Serge Y., Guha, Manti, Kijima, Takashi, Yuen, Tony, Zaidi, Mone, Avadhani, Narayan G.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6662975/
https://ncbi.nlm.nih.gov/pubmed/31063702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201900010RR
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