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Enhanced osteoclastogenesis by mitochondrial retrograde signaling through transcriptional activation of the cathepsin K gene

Mitochondrial dysfunction has emerged as an important factor in wide ranging human pathologies. We have previously defined a retrograde signaling pathway that originates from dysfunctional mitochondria (Mt-RS) and causes a global nuclear transcriptional reprograming as its endpoint. Mitochondrial dy...

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Detalhes bibliográficos
Publicado no:Ann N Y Acad Sci
Main Authors: Guha, Manti, Srinivasan, Satish, Koenigstein, Alexander, Zaidi, Mone, Avadhani, Narayan G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4575226/
https://ncbi.nlm.nih.gov/pubmed/25800988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/nyas.12709
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