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Golden Mutagenesis: An efficient multi-site-saturation mutagenesis approach by Golden Gate cloning with automated primer design

Site-directed methods for the generation of genetic diversity are essential tools in the field of directed enzyme evolution. The Golden Gate cloning technique has been proven to be an efficient tool for a variety of cloning setups. The utilization of restriction enzymes which cut outside of their re...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Püllmann, Pascal, Ulpinnis, Chris, Marillonnet, Sylvestre, Gruetzner, Ramona, Neumann, Steffen, Weissenborn, Martin J.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6662682/
https://ncbi.nlm.nih.gov/pubmed/31358887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-47376-1
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