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Golden Mutagenesis: An efficient multi-site-saturation mutagenesis approach by Golden Gate cloning with automated primer design

Site-directed methods for the generation of genetic diversity are essential tools in the field of directed enzyme evolution. The Golden Gate cloning technique has been proven to be an efficient tool for a variety of cloning setups. The utilization of restriction enzymes which cut outside of their re...

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Detalles Bibliográficos
Publicado en:Sci Rep
Main Authors: Püllmann, Pascal, Ulpinnis, Chris, Marillonnet, Sylvestre, Gruetzner, Ramona, Neumann, Steffen, Weissenborn, Martin J.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6662682/
https://ncbi.nlm.nih.gov/pubmed/31358887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-47376-1
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