9-Azido-9-deoxy-2,3-difluorosialic Acid as A Subnanomolar Inhibitor Against Bacterial Sialidases

A library of 2(e),3(a/e)-difluorosialic acids and their C-5 and/or C-9 derivatives were chemoenzymatically synthesized. Pasteurella multocida sialic acid aldolase (PmAldolase), but not its Escherichia coli homolog (EcAldolase), was found to catalyze the formation of C5-azido analog of 3-fluoro(equat...

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Vydáno v:J Org Chem
Hlavní autoři: Li, Wanqing, Santra, Abhishek, Yu, Hai, Slack, Teri J, Muthana, Musleh M, Shi, Dashuang, Liu, Yang, Chen, Xi
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6660241/
https://ncbi.nlm.nih.gov/pubmed/31083938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.9b00385
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