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Streptococcus pneumoniae Sialidase SpNanB-Catalyzed One-Pot Multienzyme (OPME) Synthesis of 2,7-Anhydro-Sialic acids as Selective Sialidase Inhibitors

Streptococcus pneumoniae sialidase SpNanB is an intramolecular trans-sialidase (IT-sialidase) and a virulence factor that is essential for streptococcal infection of upper and lower respiratory tract. SpNanB catalyzes the formation of 2,7-anhydro-N-acetylneuraminic acid (2,7-anhydro-Neu5Ac), a poten...

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Detalhes bibliográficos
Publicado no:J Org Chem
Main Authors: Xiao, An, Slack, Teri J., Li, Yanhong, Shi, Dashuang, Yu, Hai, Li, Wanqing, Liu, Yang, Chen, Xi
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6327951/
https://ncbi.nlm.nih.gov/pubmed/30105908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.8b01519
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