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Streptococcus pneumoniae Sialidase SpNanB-Catalyzed One-Pot Multienzyme (OPME) Synthesis of 2,7-Anhydro-Sialic acids as Selective Sialidase Inhibitors
Streptococcus pneumoniae sialidase SpNanB is an intramolecular trans-sialidase (IT-sialidase) and a virulence factor that is essential for streptococcal infection of upper and lower respiratory tract. SpNanB catalyzes the formation of 2,7-anhydro-N-acetylneuraminic acid (2,7-anhydro-Neu5Ac), a poten...
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| Publié dans: | J Org Chem |
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| Auteurs principaux: | , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6327951/ https://ncbi.nlm.nih.gov/pubmed/30105908 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.8b01519 |
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