Sonic Hedgehog Is a Determinant of γδ T-Cell Differentiation in the Thymus

Here we investigate the function of Hedgehog (Hh) signaling in thymic γδ T-cell maturation and subset differentiation. Analysis of Hh mutants showed that Hh signaling promotes γδ T-cell development in the thymus and influences γδ T-cell effector subset distribution. Hh-mediated transcription in thym...

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Udgivet i:Front Immunol
Main Authors: Mengrelis, Konstantinos, Lau, Ching-In, Rowell, Jasmine, Solanki, Anisha, Norris, Sonia, Ross, Susan, Ono, Masahiro, Outram, Susan, Crompton, Tessa
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6658896/
https://ncbi.nlm.nih.gov/pubmed/31379834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01629
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