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The kinesin motor protein Kif7 is required for T-cell development and normal MHC expression on thymic epithelial cells (TEC) in the thymus

Kif7 is a ciliary kinesin motor protein that regulates mammalian Hedgehog pathway activation through influencing structure of the primary cilium. Here we show that Kif7 is required for normal T-cell development, despite the fact that T-cells lack primary cilia. Analysis of Kif7-deficient thymus show...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Lau, Ching-In, Barbarulo, Alessandro, Solanki, Anisha, Saldaña, José Ignacio, Crompton, Tessa
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5421836/
https://ncbi.nlm.nih.gov/pubmed/28445929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15241
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