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Foxa1 and Foxa2 in thymic epithelial cells (TEC) regulate medullary TEC and regulatory T-cell maturation

The Foxa1 and Foxa2 transcription factors are essential for mouse development. Here we show that they are expressed in thymic epithelial cells (TEC) where they regulate TEC development and function, with important consequences for T-cell development. TEC are essential for T-cell differentiation, lin...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:J Autoimmun
Hauptverfasser: Lau, Ching-In, Yánez, Diana C., Solanki, Anisha, Papaioannou, Eleftheria, Saldaña, José Ignacio, Crompton, Tessa
Format: Artigo
Sprache:Inglês
Veröffentlicht: Academic Press 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6119767/
https://ncbi.nlm.nih.gov/pubmed/30061015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2018.07.009
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