Foxa1 and Foxa2 in thymic epithelial cells (TEC) regulate medullary TEC and regulatory T-cell maturation

The Foxa1 and Foxa2 transcription factors are essential for mouse development. Here we show that they are expressed in thymic epithelial cells (TEC) where they regulate TEC development and function, with important consequences for T-cell development. TEC are essential for T-cell differentiation, lin...

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Detalles Bibliográficos
Publicado en:J Autoimmun
Autores principales: Lau, Ching-In, Yánez, Diana C., Solanki, Anisha, Papaioannou, Eleftheria, Saldaña, José Ignacio, Crompton, Tessa
Formato: Artigo
Lenguaje:Inglês
Publicado: Academic Press 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6119767/
https://ncbi.nlm.nih.gov/pubmed/30061015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2018.07.009
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