Sonic Hedgehog signaling limits atopic dermatitis via Gli2-driven immune regulation

Hedgehog (Hh) proteins regulate development and tissue homeostasis, but their role in atopic dermatitis (AD) remains unknown. We found that on induction of mouse AD, Sonic Hedgehog (Shh) expression in skin and Hh pathway action in skin T cells were increased. Shh signaling reduced AD pathology and t...

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Detalles Bibliográficos
Publicado en:J Clin Invest
Autores principales: Papaioannou, Eleftheria, Yánez, Diana C., Ross, Susan, Lau, Ching-In, Solanki, Anisha, Chawda, Mira Manilal, Virasami, Alex, Ranz, Ismael, Ono, Masahiro, O’Shaughnessy, Ryan F. L., Crompton, Tessa
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2019
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6668675/
https://ncbi.nlm.nih.gov/pubmed/31264977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI125170
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