Sonic Hedgehog signaling limits atopic dermatitis via Gli2-driven immune regulation

Hedgehog (Hh) proteins regulate development and tissue homeostasis, but their role in atopic dermatitis (AD) remains unknown. We found that on induction of mouse AD, Sonic Hedgehog (Shh) expression in skin and Hh pathway action in skin T cells were increased. Shh signaling reduced AD pathology and t...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Papaioannou, Eleftheria, Yánez, Diana C., Ross, Susan, Lau, Ching-In, Solanki, Anisha, Chawda, Mira Manilal, Virasami, Alex, Ranz, Ismael, Ono, Masahiro, O’Shaughnessy, Ryan F. L., Crompton, Tessa
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6668675/
https://ncbi.nlm.nih.gov/pubmed/31264977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI125170
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