Sonic Hedgehog signaling limits atopic dermatitis via Gli2-driven immune regulation

Hedgehog (Hh) proteins regulate development and tissue homeostasis, but their role in atopic dermatitis (AD) remains unknown. We found that on induction of mouse AD, Sonic Hedgehog (Shh) expression in skin and Hh pathway action in skin T cells were increased. Shh signaling reduced AD pathology and t...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:J Clin Invest
Main Authors: Papaioannou, Eleftheria, Yánez, Diana C., Ross, Susan, Lau, Ching-In, Solanki, Anisha, Chawda, Mira Manilal, Virasami, Alex, Ranz, Ismael, Ono, Masahiro, O’Shaughnessy, Ryan F. L., Crompton, Tessa
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6668675/
https://ncbi.nlm.nih.gov/pubmed/31264977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI125170
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker