Sonic Hedgehog signaling limits atopic dermatitis via Gli2-driven immune regulation

Hedgehog (Hh) proteins regulate development and tissue homeostasis, but their role in atopic dermatitis (AD) remains unknown. We found that on induction of mouse AD, Sonic Hedgehog (Shh) expression in skin and Hh pathway action in skin T cells were increased. Shh signaling reduced AD pathology and t...

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Detaylı Bibliyografya
Yayımlandı:J Clin Invest
Asıl Yazarlar: Papaioannou, Eleftheria, Yánez, Diana C., Ross, Susan, Lau, Ching-In, Solanki, Anisha, Chawda, Mira Manilal, Virasami, Alex, Ranz, Ismael, Ono, Masahiro, O’Shaughnessy, Ryan F. L., Crompton, Tessa
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2019
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6668675/
https://ncbi.nlm.nih.gov/pubmed/31264977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI125170
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