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Utilization of CRISPR Interference To Validate MmpL3 as a Drug Target in Mycobacterium tuberculosis
There is an urgent need for novel therapeutics to treat Mycobacterium tuberculosis infections. Genetic strategies for validating novel targets are available, yet their time-consuming nature limits their utility. Here, using MmpL3 as a model target, we report on the application of mycobacterial CRISP...
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| Publicado no: | Antimicrob Agents Chemother |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6658742/ https://ncbi.nlm.nih.gov/pubmed/31160289 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00629-19 |
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