Novel Insights into the Mechanism of Inhibition of MmpL3, a Target of Multiple Pharmacophores in Mycobacterium tuberculosis

MmpL3, a resistance-nodulation-division (RND) superfamily transporter, has been implicated in the formation of the outer membrane of Mycobacterium tuberculosis; specifically, MmpL3 is required for the export of mycolic acids in the form of trehalose monomycolates (TMM) to the periplasmic space or ou...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Li, Wei, Upadhyay, Ashutosh, Fontes, Fabio L., North, E. Jeffrey, Wang, Yuehong, Crans, Debbie C., Grzegorzewicz, Anna E., Jones, Victoria, Franzblau, Scott G., Lee, Richard E., Crick, Dean C., Jackson, Mary
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249373/
https://ncbi.nlm.nih.gov/pubmed/25136022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03229-14
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