1H-Benzo[d]Imidazole Derivatives Affect MmpL3 in Mycobacterium tuberculosis

1H-benzo[d]imidazole derivatives exhibit antitubercular activity in vitro at a nanomolar range of concentrations and are not toxic to human cells, but their mode of action remains unknown. Here, we showed that these compounds are active against intracellular Mycobacterium tuberculosis. To identify t...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Korycka-Machała, Małgorzata, Viljoen, Albertus, Pawełczyk, Jakub, Borówka, Paulina, Dziadek, Bożena, Gobis, Katarzyna, Brzostek, Anna, Kawka, Malwina, Blaise, Mickael, Strapagiel, Dominik, Kremer, Laurent, Dziadek, Jarosław
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2019
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Mechanisms of Action: Physiological Effects
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6761528/
https://ncbi.nlm.nih.gov/pubmed/31332069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00441-19
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