Multiple Mutations in Mycobacterium tuberculosis MmpL3 Increase Resistance to MmpL3 Inhibitors

The Mycobacterium tuberculosis protein MmpL3 performs an essential role in cell wall synthesis, since it effects the transport of trehalose monomycolates across the inner membrane. Numerous structurally diverse pharmacophores have been identified as inhibitors of MmpL3 largely based on the identific...

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Bibliografiska uppgifter
I publikationen:mSphere
Huvudupphovsmän: McNeil, Matthew B., O’Malley, Theresa, Dennison, Devon, Shelton, Catherine D., Sunde, Bjorn, Parish, Tanya
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2020
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7565900/
https://ncbi.nlm.nih.gov/pubmed/33055263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSphere.00985-20
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