Two-Way Regulation of MmpL3 Expression Identifies and Validates Inhibitors of MmpL3 Function in Mycobacterium tuberculosis

[Image: see text] MmpL3, an essential mycolate transporter in the inner membrane of Mycobacterium tuberculosis (Mtb), has been identified as a target of multiple, chemically diverse antitubercular drugs. However, several of these molecules seem to have secondary targets and inhibit bacterial growth...

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Udgivet i:ACS Infect Dis
Main Authors: Grover, Shipra, Engelhart, Curtis A., Pérez-Herrán, Esther, Li, Wei, Abrahams, Katherine A., Papavinasasundaram, Kadamba, Bean, James M., Sassetti, Christopher M., Mendoza-Losana, Alfonso, Besra, Gurdyal S., Jackson, Mary, Schnappinger, Dirk
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2020
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7802072/
https://ncbi.nlm.nih.gov/pubmed/33319550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.0c00675
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