Sequential Open-Label Study of the Safety, Tolerability, and Pharmacokinetic Interactions between Dihydroartemisinin-Piperaquine and Mefloquine in Healthy Thai Adults

Artemisinin-based combination therapies (ACTs) have contributed substantially to the global decline in Plasmodium falciparum morbidity and mortality, but resistance to artemisinins and their partner drugs is increasing in Southeast Asia, threatening malaria control. New antimalarial compounds will n...

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Publicado en:Antimicrob Agents Chemother
Autores principales: Hanboonkunupakarn, Borimas, van der Pluijm, Rob W., Hoglund, Richard, Pukrittayakamee, Sasithon, Winterberg, Markus, Mukaka, Mavuto, Waithira, Naomi, Chotivanich, Kesinee, Singhasivanon, Pratap, White, Nicholas J., Dondorp, Arjen M., Tarning, Joel, Jittamala, Podjanee
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2019
Materias:
Pharmacology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6658739/
https://ncbi.nlm.nih.gov/pubmed/31182525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00060-19
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