Secondary Lymphoid Tissue and Costimulation-Blockade Resistant Rejection: A Nonhuman Primate Renal Transplant Study

Naïve T cell activation requires antigen presentation combined with costimulation through CD28, both of which optimally occur in secondary lymphoid tissues such as lymph nodes and the spleen. Belatacept impairs CD28 costimulation by binding its ligands, CD80 and CD86, and in doing so, impairs de nov...

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Veröffentlicht in:Am J Transplant
Hauptverfasser: Mulvihill, Michael S, Samy, Kannan P, Gao, Qimeng A, Schmitz, Robin, Davis, Robert P, Ezekian, Brian, Leopardi, Francis, Song, Mingqing, How, Tam, Williams, Kyha, Barbas, Andrew, Collins, Bradley, Kirk, Allan D
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6658331/
https://ncbi.nlm.nih.gov/pubmed/30891931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ajt.15365
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