Selective Targeting of High-Affinity LFA-1 Does Not Augment Costimulation Blockade in a Nonhuman Primate Renal Transplantation Model

Costimulation blockade (CoB) via belatacept is a lower morbidity alternative to calcineurin inhibitor (CNI)-based immunosuppression. However, it has higher rates of early acute rejection. These early rejections are mediated in part by memory T cells, which have reduced dependence on the pathway targ...

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Detalles Bibliográficos
Publicado en:Am J Transplant
Autores principales: Samy, KP, Anderson, DA, Lo, DJ, Mulvihill, MS, Song, M, Farris, AB, Parker, BS, MacDonald, AL, Lu, C, Springer, TA, Kachlany, SC, Reimann, KA, How, T, Leopardi, FV, Franke, KS, Williams, KD, Collins, BH, Kirk, AD
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409867/
https://ncbi.nlm.nih.gov/pubmed/27888551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ajt.14141
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