The Role of Human CD46 in Early Xenoislet Engraftment in a Dual Transplant Model

BACKGROUND: Membrane cofactor protein CD46 attenuates the complement cascade by facilitating cleavage of C3b and C4b. In solid organ xenotransplantation, organs expressing CD46 have been shown to resist hyperacute rejection. However, the incremental value of human CD46 expression for islet xenotrans...

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Detalhes bibliográficos
Publicado no:Xenotransplantation
Main Authors: Samy, KP, Gao, Q, Davis, RP, Song, M, Fitch, ZW, Mulvihill, MS, MacDonald, A, Leopardi, FV, How, T, Williams, KD, Devi, GR, Collins, BH, Luo, X, Kirk, AD
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6908747/
https://ncbi.nlm.nih.gov/pubmed/31219218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/xen.12540
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