Integrative analysis of loss-of-function variants in clinical and genomic data reveals novel genes associated with cardiovascular traits

BACKGROUND: Genetic loss-of-function variants (LoFs) associated with disease traits are increasingly recognized as critical evidence for the selection of therapeutic targets. We integrated the analysis of genetic and clinical data from 10,511 individuals in the Mount Sinai BioMe Biobank to identify...

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Publicado en:BMC Med Genomics
Autores principales: Glicksberg, Benjamin S., Amadori, Letizia, Akers, Nicholas K., Sukhavasi, Katyayani, Franzén, Oscar, Li, Li, Belbin, Gillian M., Akers, Kristin L., Shameer, Khader, Badgeley, Marcus A., Johnson, Kipp W., Readhead, Ben, Darrow, Bruce J., Kenny, Eimear E., Betsholtz, Christer, Ermel, Raili, Skogsberg, Josefin, Ruusalepp, Arno, Schadt, Eric E., Dudley, Joel T., Ren, Hongxia, Kovacic, Jason C., Giannarelli, Chiara, Li, Shuyu D., Björkegren, Johan L. M., Chen, Rong
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6657044/
https://ncbi.nlm.nih.gov/pubmed/31345219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12920-019-0542-3
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