Cardiometabolic Risk Loci Share Downstream Cis- and Trans-Gene Regulation Across Tissues and Diseases

Genome-wide association studies (GWAS) have identified hundreds of cardiometabolic disease (CMD) risk loci. However, they contribute little to genetic variance, and most downstream gene-regulatory mechanisms are unknown. We genotyped and RNA-sequenced vascular and metabolic tissues from 600 coronary...

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Udgivet i:Science
Main Authors: Franzén, Oscar, Ermel, Raili, Cohain, Ariella, Akers, Nicholas K., Di Narzo, Antonio, Talukdar, Husain A., Foroughi-Asl, Hassan, Giambartolomei, Claudia, Fullard, John F., Sukhavasi, Katyayani, Köks, Sulev, Gan, Li-Ming, Giannarelli, Chiara, Kovacic, Jason C., Betsholtz, Christer, Losic, Bojan, Michoel, Tom, Hao, Ke, Roussos, Panos, Skogsberg, Josefin, Ruusalepp, Arno, Schadt, Eric E., Björkegren, Johan L.M.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5534139/
https://ncbi.nlm.nih.gov/pubmed/27540175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad6970
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