Global analysis of A-to-I RNA editing reveals association with common disease variants

RNA editing modifies transcripts and may alter their regulation or function. In humans, the most common modification is adenosine to inosine (A-to-I). We examined the global characteristics of RNA editing in 4,301 human tissue samples. More than 1.6 million A-to-I edits were identified in 62% of all...

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Detalhes bibliográficos
Publicado no:PeerJ
Main Authors: Franzén, Oscar, Ermel, Raili, Sukhavasi, Katyayani, Jain, Rajeev, Jain, Anamika, Betsholtz, Christer, Giannarelli, Chiara, Kovacic, Jason C., Ruusalepp, Arno, Skogsberg, Josefin, Hao, Ke, Schadt, Eric E., Björkegren, Johan L.M.
Formato: Artigo
Idioma:Inglês
Publicado em: PeerJ Inc. 2018
Assuntos:
Computational Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5844249/
https://ncbi.nlm.nih.gov/pubmed/29527417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7717/peerj.4466
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