Physiologically‐Based Pharmacokinetic Modeling of Fluconazole Using Plasma and Cerebrospinal Fluid Samples From Preterm and Term Infants

Fluconazole is used to treat hematogenous Candida meningoencephalitis in preterm and term infants. To characterize plasma and central nervous system exposure, an adult fluconazole physiologically‐based pharmacokinetic (PBPK) model was scaled to infants, accounting for age dependencies in glomerular...

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Bibliografische gegevens
Gepubliceerd in:CPT Pharmacometrics Syst Pharmacol
Hoofdauteurs: Gerhart, Jacqueline G., Watt, Kevin M., Edginton, Andrea, Wade, Kelly C., Salerno, Sara N., Benjamin, Daniel K., Smith, P. Brian, Hornik, Christoph P., Cohen‐Wolkowiez, Michael, Duara, Shahnaz, Ross, Ashley, Shattuck, Karen, Stewart, Dan L., Neu, Natalie, Gonzalez, Daniel
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2019
Onderwerpen:
Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6656941/
https://ncbi.nlm.nih.gov/pubmed/31087536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12414
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