Development of an Adult Physiologically Based Pharmacokinetic Model of Solithromycin in Plasma and Epithelial Lining Fluid

Solithromycin is a fluoroketolide antibiotic under investigation for community‐acquired bacterial pneumonia (CABP). We developed a whole‐body physiologically based pharmacokinetic (PBPK) model for solithromycin in adults using PK‐Sim and MoBi version 6.2, which incorporated time‐dependent CYP3A4 aut...

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Detalhes bibliográficos
Publicado no:CPT Pharmacometrics Syst Pharmacol
Main Authors: Salerno, Sara N., Edginton, Andrea, Cohen‐Wolkowiez, Michael, Hornik, Christoph P., Watt, Kevin M., Jamieson, Brian D., Gonzalez, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5744174/
https://ncbi.nlm.nih.gov/pubmed/29068158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12252
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