Physiologically‐Based Pharmacokinetic Modeling of Fluconazole Using Plasma and Cerebrospinal Fluid Samples From Preterm and Term Infants

Fluconazole is used to treat hematogenous Candida meningoencephalitis in preterm and term infants. To characterize plasma and central nervous system exposure, an adult fluconazole physiologically‐based pharmacokinetic (PBPK) model was scaled to infants, accounting for age dependencies in glomerular...

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Bibliografske podrobnosti
izdano v:CPT Pharmacometrics Syst Pharmacol
Main Authors: Gerhart, Jacqueline G., Watt, Kevin M., Edginton, Andrea, Wade, Kelly C., Salerno, Sara N., Benjamin, Daniel K., Smith, P. Brian, Hornik, Christoph P., Cohen‐Wolkowiez, Michael, Duara, Shahnaz, Ross, Ashley, Shattuck, Karen, Stewart, Dan L., Neu, Natalie, Gonzalez, Daniel
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2019
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6656941/
https://ncbi.nlm.nih.gov/pubmed/31087536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12414
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