Physiologically‐Based Pharmacokinetic Modeling of Fluconazole Using Plasma and Cerebrospinal Fluid Samples From Preterm and Term Infants

Fluconazole is used to treat hematogenous Candida meningoencephalitis in preterm and term infants. To characterize plasma and central nervous system exposure, an adult fluconazole physiologically‐based pharmacokinetic (PBPK) model was scaled to infants, accounting for age dependencies in glomerular...

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Detalhes bibliográficos
Publicado no:CPT Pharmacometrics Syst Pharmacol
Main Authors: Gerhart, Jacqueline G., Watt, Kevin M., Edginton, Andrea, Wade, Kelly C., Salerno, Sara N., Benjamin, Daniel K., Smith, P. Brian, Hornik, Christoph P., Cohen‐Wolkowiez, Michael, Duara, Shahnaz, Ross, Ashley, Shattuck, Karen, Stewart, Dan L., Neu, Natalie, Gonzalez, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6656941/
https://ncbi.nlm.nih.gov/pubmed/31087536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12414
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