Physiologically‐Based Pharmacokinetic Modeling of Fluconazole Using Plasma and Cerebrospinal Fluid Samples From Preterm and Term Infants

Fluconazole is used to treat hematogenous Candida meningoencephalitis in preterm and term infants. To characterize plasma and central nervous system exposure, an adult fluconazole physiologically‐based pharmacokinetic (PBPK) model was scaled to infants, accounting for age dependencies in glomerular...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:CPT Pharmacometrics Syst Pharmacol
Autors principals: Gerhart, Jacqueline G., Watt, Kevin M., Edginton, Andrea, Wade, Kelly C., Salerno, Sara N., Benjamin, Daniel K., Smith, P. Brian, Hornik, Christoph P., Cohen‐Wolkowiez, Michael, Duara, Shahnaz, Ross, Ashley, Shattuck, Karen, Stewart, Dan L., Neu, Natalie, Gonzalez, Daniel
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2019
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6656941/
https://ncbi.nlm.nih.gov/pubmed/31087536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12414
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars