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Safety and Pharmacokinetics of Solithromycin in Subjects with Hepatic Impairment

Solithromycin, a new macrolide and the first fluoroketolide, is in late-stage clinical development and, like older macrolides, is primarily metabolized and excreted through liver-dependent mechanisms. This study evaluated the safety and pharmacokinetics of solithromycin in patients with chronic live...

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Détails bibliographiques
Publié dans:Antimicrob Agents Chemother
Auteurs principaux: Jamieson, Brian D., Ciric, Sabrina, Fernandes, Prabhavathi
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505280/
https://ncbi.nlm.nih.gov/pubmed/25870056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04652-14
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