Multiplex quantitative analysis of cancer-associated fibroblasts and immunotherapy outcome in metastatic melanoma

BACKGROUND: The cancer-associated fibroblast (CAF) population is implicated in immune dysregulation. Here, we test the hypothesis that CAF profiles in pretreatment tumor specimens are associated with response to immune checkpoint blockade of programmed cell death 1 (PD-1). METHODS: Pretreatment whol...

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Gepubliceerd in:J Immunother Cancer
Hoofdauteurs: Wong, Pok Fai, Wei, Wei, Gupta, Swati, Smithy, James W., Zelterman, Daniel, Kluger, Harriet M., Rimm, David L.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2019
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6651990/
https://ncbi.nlm.nih.gov/pubmed/31337426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-019-0675-0
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